Seriously man... Germaine and Foamy...
Lately there's been a three part story about Germaine's past and her weird psychoses, and honestly, I LIKE the way it's turned out. I think they've put a really neat, self-aware tie on the strange Neurotically Yours series as it's been over the last ten freaking years. Instead of doing some blatant horror fakeout all-a-dream "ending", they seem to be establishing more canon, explaining some things, and making a genuine set of mechanics for how Germaine's brain works. I'm kind of... Attached to these characters now.
I don't think the cartoon is actually over, and I hope it continues for a good while, but if it finished now, I would be happy with its ending. Even if some stuff isn't quite resolved...